Psychedelics

Phase 2 Clinical Trial of LSD for "Suicide Headaches" Begins Treating Patients

From yesterday’s PR Newswire press release:

Mind Medicine (MindMed) Inc. (NEO: MMEDOTCQB: MMEDF), is supporting and collaborating on a Phase 2 clinical trial evaluating LSD for the treatment of cluster headaches at University Hospital Basel's Liechti Lab. The Phase 2 trial began recruiting patients in early January and has commenced treating patients with LSD.

The idea of treating cluster headaches with psychedelics isn’t new—people have been experimenting with it for decades—but there hasn’t been much research conducted on it yet. I’m curious to see how this trial turns out and hope that we see more research in this area soon.


Children and Psychedelics

Rebecca Kronman, writing for Chacruna:

For Westerners, the topic of children and psychedelics is a near-untouchable one, mired in taboo and stigma. Many find the idea of allowing children to ingest psychedelics, or even be in their presence, dangerous and irresponsible. As we stand on the precipice of greater access to these substances, it may be time to examine the views that have governed our mode of thinking by reaching outside of the Western canon.

As an aspiring future parent, I am very interested in the topic of psychedelic parenting. In this enlightening article, Kronman explores the differences between how indigenous societies view the idea of exposing children to powerful psychoactive drugs vs. we view it in the West.

Caution is most certainly warranted. Psychedelics are illegal in many countries and there hasn’t been a whole lot of research conducted in this area. But that doesn’t mean that Western parents should avoid introducing psychedelics to their children altogether. Indigenous cultures certainly don’t feel that way:

Unlike Western culture, where adults are cautioned to keep psychoactive substances away from children, in indigenous cultures, children may be involved in the harvest, ceremony, and ingestion of substances in both small and full doses. During the 2019 Horizons conference, speaker Steven Bennally, Board Director of the Indigenous Peyote Conservation Initiative, showed images of elders in his community harvesting peyote buttons with young children. During this time together, he said, the adults took the opportunity to teach children that when something is taken from the earth, something must be given back.

So children in indigenous cultures are often involved with the harvesting of psychedelics. And they become familiar with ceremonies at an early age, too.

Children are often present in ceremony while the adults ingest a substance. In some traditions, young children are given varying amounts of the substance as part of an initiation ritual. The Huichol Indians in Mexico give small doses of peyote to their children around age six, or “the age of understanding,” when they can verbally articulate their experiences; larger vision-inducing doses are given around age eight. Similarly, members of the Fang tribe in Gabon administer ibogaine to children around age eight to ten. Parents who are Santo Daime Church members give miniscule doses of ayahuasca to babies just hours old.

Some societies start introducing babies to psychedelics before they are even born:

Even before early childhood, some indigenous cultures, like the Huichol Indians of Mexico and members of the Native American Church (NAC) in the United States and Canada, utilize plant medicines prenatally or during breastfeeding to help prevent miscarriage, ensure the maturation of the fetus, and increase breastmilk production In fact, the story of a pregnant woman ingesting peyote is woven into the NAC Peyote Woman mythology, where a pregnant woman is lost in the desert and starving, and is called to ingest peyote, which helps her deliver the child with ease.

Responsible approaches to psychedelic parenting have evolved over time in many indigenous cultures. Those of us in the West stand to learn a lot from them, assuming we are willing to listen. I’m excited to see this topic being discussed more often and look forward to future research that helps us better understand the ramifications of exposing children to psychedelics.


Not All Ayahuasca Is Made Equal

Jasmine Virdi, writing for Psychedelics Today:

As the use of ayahuasca becomes increasingly widespread, the Amazonian vine has extended its roots beyond the traditional indigenous and religious contexts of South America, lending itself to a newly evolving field of practice. However, the economic viability of ayahuasca ceremonies combined with the vine’s complicated legal status opens the field to a plurality of malpractice, particularly when it comes to what practitioners actually serve in the cup.

Since it is a plant medicine, ayahuasca naturally varies in quality (including differences in strength, chemical makeup, psychoactive and physical effect, and taste) depending on the plants that are used, where those plants come from, the skill of the person concocting the brew, and other factors. To better understand this phenomenon, researchers from Estonia and Brazil analyzed the differences in ayahuasca brews from multiple traditions:

Their study, yet to be published, analyzed changing distributions of DMT, harmine, harmaline, and tetrahydroharmine (THH) across 102 ayahuasca samples. These samples were taken from different locations in Europe and Brazil, spanning across different traditions including indigenous shamanic, Santo Daime, and neo-shamanic.

Interesting tendencies emerged based on the traditions from which the samples came, with indigenous brews showing a balanced ratio between the concentrations of DMT, THH, and harmine. Samples that came from the ayahuasca religion, Santo Daime, also showed a similar balance between chemical compounds, although some brews tended towards increased concentrations of DMT.

However, when it came to brews received from neo-shamanic facilitators of different backgrounds, there was notably more variation between chemical constituents, and on average, they contained substantially greater concentrations of DMT than indigenous brews.

This study found that the ayahuasca brewed in indigenous communities and the Santo Daime church is more consistent than the brews made by neo-shamans. Perhaps not surprisingly, neo-shamanic brews are more likely to include additional additives and contaminants, and some neo-shamans are effectively creating a counterfeit product and attempting to pass it off as legitimate ayahuasca. That’s because so-called “anahuasca” and “pharmahuasca” brews are not made from traditional plants but instead use different plants, fungi, or pharmaceutical drugs to imitate the effects of classical ayahuasca. Interestingly, this practice is virtually nonexistent within more established ayahuasca traditions:

Comparatively, there was no counterfeit ayahuasca found among disciplined ayahuasca traditions such as the Santo Daime and among indigenous practitioners. In South America in general, the raw materials to make ayahuasca are both abundant and affordable, removing any incentive to replace them with other plants or pharmaceuticals.

Kronman argues that “we as a community [need to] work to develop self-regulating mechanisms that foster and encourage transparent practices” and I agree. The issue is not that alternative brews should be avoided altogether (I’m all for responsible psychoactive experimentation), but rather that people who drink ayahuasca should always be informed about the specific plants that were used in the brew, and they should absolutely steer clear of drinking with facilitators who aren’t fully transparent about what is in their ayahuasca brew or act offended when asked what ingredients are in it.


Tech Startup Unveils Futuristic Anti-Virus Bodysuit with Vaping Capabilities

Zach Harris, writing for MERRY JANE:

As quarantine continues with no end in sight, people are getting restless. But more than just going back to work or dining in a restaurant, companies are beginning to explore what our favorite pastimes might look like in a future marred by viral fear. For one California tech startup, that means festival-goers watching concerts through sealed super suits with built-in beverage and vape consumption modules.

According to Fast Company, Los Angeles-based tech startup Production Club is already knee-deep in the process of designing what they call the Micrashell — an airtight half-suit and helmet that would encase the wearer for the entirety of any given festival. To ensure that those wearing the suit can easily use the bathroom, or do other things that don’t involve pants (wink, wink…), the prototype only covers the top half of the body.

An antivirus bodysuit for festivalgoers that will enable them to vape, drink, and have sex in a world ravaged by contagious disease? Sign. Me. Up.


Go Take the Global Drug Survey: COVID-19 Special Edition

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It’s that time of year again! “What time of year are you talking about?”, you ask? It’s time to take the Global Drug Survey, of course. Well, kinda…

If you’ve been a Think Wilder reader for a while then you know that the Global Drug Survey opens back up at the end of every year, asking people all around the world about their relationship with drugs. But even though it seems like 2020 has already gone on for longer than a year, it’s not even summer yet. So why is GDS actively seeking responses right now?

Earlier this month Global Drug Survey launched a brand-new special edition of its annual survey that focuses on how the COVID-19 pandemic is affecting people’s lives, relationships, mental health and well-being, as well as their use of alcohol and other drugs.

It only takes about 15 minutes to take, assuming that you have only used alcohol during the last few months, and an additional 10 minutes if you have used other drugs.

After completing your survey you will also be given the option to take part in an additional longitudinal cohort study that will track alcohol and other drug use patterns over time. Those who decide to participate in the cohort will receive short follow-up surveys every 30 days to monitor how things progress throughout the pandemic and beyond.

I reached out to Dr. Adam Winstock, the founder of GDS, to ask when the survey collection period will end. He let me know that the organization is hoping to launch all other countries by this Saturday and that people will have until mid-June to submit their responses.

The COVID-19 special edition of the Global Drug Survey is an excellent way to contribute to the collection of data that will be used to better understand substance use trends during the pandemic. I filled out my survey a couple days ago and encourage you to do the same.

Stay safe out there, y’all.