Psychedelics

Psychedelic Mushrooms Grew in a Man’s Veins After He Injected Them

Ed Cara, writing for Gizmodo:

A man’s experiment with psychedelic mushrooms went disastrously wrong and nearly killed him, according to his doctors. In a new case report released this week, they detailed how the man injected a “tea” made from the mushrooms into his body and developed a life-threatening infection that had them growing in his blood. The experience left him in the hospital for close to a month. Fortunately, he survived.

It may seem obvious for experienced psychonauts to simply say “Don’t do this—what a dumbass”, and I’ve seen a lot of people saying that over the last 24 hours. But in all fairness to the man who did do this, he was an opioid user, not someone with a history of psychedelic use:

According to the report, the 30-year-old man had been brought to the emergency room by his family after exhibiting confusion. He had a history of bipolar disorder as well as opioid dependence and had recently stopped taking his prescribed medications, his family told doctors. In the course of trying to self-medicate his depression and dependence, he came across research showing some benefit from using psychedelic drugs like mushrooms and LSD.

Days before the ER visit, he had decided to use mushrooms by first boiling them down into what he called “mushroom tea,” then filtering the mixture through a cotton swab and intravenously injecting it. Soon after, he developed symptoms including lethargy, jaundice, diarrhea, and nausea, along with vomiting up blood.

It’s easy to judge other people without taking into account the fact that they lack the education and experience that you have gained, but that doesn’t make it right. Thankfully the man survived, and on top of that, something completely unexpected happened:

By the time he was admitted to the hospital’s intensive care unit, multiple organs had started to fail, including his lungs and kidney. Tests revealed that he had both a bacterial and fungal infection in his blood, likely meaning that the mushrooms he injected were now literally feeding off him and growing, the doctors wrote (the fungus found in the man’s blood was the same species of psychedelic mushroom he had injected). Among other treatments, he was given an intense course of antibiotics and antifungal drugs.

It took 22 days in the hospital, including eight in the ICU, but the man did eventually pull through. At the time his doctors had finished writing the case up, though, he was still being treated with a long-term course of antimicrobials.

So it turns out that if you inject psilocybin mushrooms you might end up growing psilocybin in your own body, which is truly a nightmare scenario. Even if you already knew to not inject psilocybin, the fact that it’s able to reproduce inside the human body is a new discovery in and of itself.

As for the man, he is currently still alive and hopefully will have a swift and full recovery. If he gets the chance to work with psilocybin again I hope he’ll drink the tea instead of injecting it next time.

Be nice out there y’all. Help educate others rather than shaming them. Be a living example of a responsible psychonaut, not a condescending jerk.


Should You Say ‘I Love You’ While on MDMA?

Earlier this week DoubleBlind published an article titled “Should You Say ‘I Love You’ While On MDMA?” that explores the possibility of hurting others by saying you love them when you don’t really authentically feel that way:

[Sophia] was wandering through the LGBTQ Pride Celebration in San Francisco when she ran into Simon and Mia, a pair of twins who she knew from childhood, though they had grown apart over the years. “We love you so much!” they exclaimed, hugging her repeatedly. Sophia was surprised, but she embraced the situation. The twins expressed interest in rekindling the friendship and exchanged phone numbers with her. After they parted ways, Sophia felt grateful for the interaction. However, neither Simon nor Mia ever contacted her, and never returned her messages; this was disappointing, confusing, and hurtful for Sophia. When she spoke to a friend who had been present at the original encounter, they said that the twins had been quite obviously under the influence of MDMA.

Jeff had taken MDMA with his roommates and was still very much feeling the effects when his partner Anna, who was sober, came over that evening. Jeff had been having some doubts about their relationship, but when they cuddled in bed together he was overcome with intense feelings of intimacy and tenderness. After having passionate sex, he told Anna that he loved her for the first time and she took his words seriously. However, he realized the next day, with tremendous guilt and regret, that the feeling was gone, and decided that it hadn’t been genuine love to start with. His words that night created a great deal of emotional pain for Anna and himself; their relationship ended messily several weeks later.

These true stories, which are taken from interviews I conducted over the past year, illustrate how interpersonal harm can arise when people who are under the influence of MDMA tell others that they love them. In both cases, the harm came from the recipient interpreting the words of love in a certain way, then discovering later that the words did not mean what they initially thought. Sophia and Anna understood these words as expressing real, authentic love that would persist into the future. When the feelings disappeared afterwards, both women doubted that love was ever present in the first place.

While I agree this is definitely a potential pitfall for MDMA users, I also know that in my own personal experience the exact opposite has been true.

Eight years ago during the peak of an MDMA experience I told a girl I was dating that I loved her. We were at a show (Big Gigantic, if you care to know) and I blurted it our uncontrollably while we were dancing together. That girl later became my wife, and we’re currently living happily ever after.

Not every Molly-inspired instance of “I love you” is inauthentic. (And to be clear, the DoubleBlind article doesn’t attempt to defend that idea.)

The main difference between situations like mine and the ones described in the quoted text above is that I had already realized that I loved the girl I was dating before taking MDMA. It’s definitely worth considering the veracity of statements while under the influence of psychoactive drugs like MDMA, but it requires a certain level of self-awareness and skill that many people have not developed.

So should you say “I love you” while rolling? Every situation is different, but it’s definitely wise to proceed with caution in this area so as to avoid hurting someone’s feelings in the long run.


COMPASS Pathways Is Building a Psychedelic Research Center

COMPASS Pathways:

COMPASS Pathways plc (Nasdaq: CMPS) (“COMPASS”), a mental health care company dedicated to accelerating patient access to evidence-based innovation in mental health, is establishing its first Centre of Excellence in collaboration with The Sheppard Pratt Institute for Advanced Diagnostics and Therapeutics in Baltimore, Maryland, United States.

The Centre of Excellence will model the “clinic of the future”, showcasing the best thinking in science, therapy, technology, and design. Working as a research facility and innovation lab, it will generate evidence to shape therapy models in mental health care, train and certify therapists, conduct clinical trials including proof-of-concept studies, and prototype digital solutions to improve patient experience. The first wave of research will focus on COMPASS’s investigational COMP360 psilocybin therapy, which comprises administration of COMP360 psilocybin with psychological support from specially trained therapists.


Amsterdam Planning to Ban Tourists From Coffeeshops

Francesca Street, writing for CNN:

When international tourists finally return to the canal-lined historic streets of Amsterdam, one of the city's main travel attractions might be off limits.

Amsterdam Mayor Femke Halsema has proposed a new policy that would ban foreign visitors from accessing the city's coffee shops.

There are several reasons why people like traveling to Amsterdam—captivating museums, historic churches and castles, gorgeous fields of tulips, lazy canal rides, refreshing public parks, scrumptious stroopwafels, and the allure of legal prostitutes. But one of the most compelling reasons that tourists flock to the city is to visit the coffeeshops:

[An August 2019 survey] questioned 1,100 international visitors between the ages of 18 and 35 who were visiting Amsterdam's Red Light District, an area of the city that's been the focus of much of Amsterdam's most recent tourism regulations.

In this survey, referenced in Halsema's most recent correspondence, over half of those surveyed said they chose to visit the Dutch capital because they wanted to experience a cannabis cafe.

The results were that 34% indicated they'd come to Amsterdam less often if they weren't able to visit coffee shops, and 11% said they wouldn't come at all.

For a long time Amsterdam was the gold standard for buying and consuming cannabis in public, but those days are coming to an end now that there so many other places in the world that allow people to do those things. Hopefully this legislation won’t pass, because I’d like to return to Amsterdam and visit some coffeeshops in the post-pandemic world. But even if it does, I could see it getting overturned in the future after more countries legalize marijuana.

And if you’re wondering what the number one reason that people visit Amsterdam is, it turns out that it’s actually pretty wholesome and healthy:

While Amsterdam's 2019 tourist survey suggested coffee shops have a strong appeal for visitors, those surveyed said the most common reason for visiting Amsterdam isn't the coffee shops, the Red Light District or even the city's museums and cultural attractions.

Instead, visitors championed the pretty wholesome appeal of walking or cycling around the city.

Banning tourists from coffeeshops most likely won’t kill tourism in Amsterdam, but it certainly would diminish it quite a bit.


Entheon Biomedical to Explore DMT for Substance Use Disorders

Ruairi J MacKenzie, writing for Technology Networks:

Substance use disorders have a debilitating impact on the wellbeing of individuals and their families. Like many other mental health disorders, these conditions have proved stubbornly resistant to treatment. The potential of psychedelic compounds to treat substance use disorders has led Canadian R&D company Entheon Biomedical to investigate the therapeutic use of the psychedelic dimethyltryptamine (DMT). The company has commissioned a clinical trial investigating the safety and efficacy of intravenous DMT. Technology Networks spoke to Entheon’s CEO, Timothy Ko, to find out more.

Could DMT be helpful for treating substance use disorders? Perhaps, although again I think a longer-lasting classical psychedelic drug such as psilocybin mushrooms, ayahuasca, or LSD would have a better chance for this particular application. But I’ll hold my final judgment until we have some solid scientific evidence indicating one way or another.